The Cayenne’s pre-crash front seatbelts will tighten automatically in the event the vehicle detects an impending crash, improving protection against injury significantly. The GX doesn’t offer pre-crash pretensioners.
Both the Cayenne and GX have child safety locks to prevent children from opening the rear doors. The Cayenne has power child safety locks, allowing the driver to activate and deactivate them from the driver's seat and to know when they're engaged. The GX’s child locks have to be individually engaged at each rear door with a manual switch. The driver can’t know the status of the locks without opening the doors and checking them.
A passive infrared night vision system optional on the Cayenne helps the driver to more easily detect people, animals or other objects in front of the vehicle at night. Using an infrared camera to detect heat, the system then displays the image on a monitor in the dashboard. The GX doesn’t offer a night vision system.
To deliver safety and visibility under dusty conditions the Porsche Cayenne’s backup monitor has a standard rear washer to keep the view clear. A camera washer system costs extra on the Lexus GX.
For better protection of the passenger compartment, the Cayenne uses safety cell construction with a three-dimensional high-strength frame that surrounds the passenger compartment. It provides extra impact protection and a sturdy mounting location for door hardware and side impact beams. The GX uses a body-on-frame design, which has no frame members above the floor of the vehicle.
Both the Cayenne and the GX have standard driver and passenger frontal airbags, front side-impact airbags, driver and front passenger knee airbags, side-impact head airbags, front seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, all wheel drive, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, post-collision automatic braking systems, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning and driver alert monitors.

