The Cayenne Coupe’s pre-crash front seatbelts will tighten automatically in the event the vehicle detects an impending crash, improving protection against injury significantly. The Grand Cherokee doesn’t offer pre-crash pretensioners.
Both the Cayenne Coupe and Grand Cherokee have child safety locks to prevent children from opening the rear doors. The Cayenne Coupe has power child safety locks, allowing the driver to activate and deactivate them from the driver's seat and to know when they're engaged. The Grand Cherokee’s child locks have to be individually engaged at each rear door with a manual switch. The driver can’t know the status of the locks without opening the doors and checking them.
The Cayenne Coupe has a standard Multi-collision Brake System, which automatically applies the brakes in the event of a crash to help prevent secondary collisions and prevent further injuries. The Grand Cherokee doesn’t offer a post collision braking system: in the event of a collision that triggers the airbags, more collisions are possible without the protection of airbags that may have already deployed.
To provide maximum traction and stability on all roads, All-Wheel Drive is standard on the Cayenne Coupe. But it costs extra on the Grand Cherokee.
To deliver safety and visibility under dusty conditions the Porsche Cayenne Coupe’s backup monitor has a standard rear washer to keep the view clear. A camera washer system costs extra on the Jeep Grand Cherokee.
Both the Cayenne Coupe and Grand Cherokee have rear cross-traffic warning, but the Cayenne Coupe has Rear Cross Traffic Alert (automatically applies the brakes) to better prevent a collision when backing near traffic. The Grand Cherokee’s Rear Cross Path Detection doesn’t automatically brake.
Both the Cayenne Coupe and the Grand Cherokee have standard driver and passenger frontal airbags, front side-impact airbags, driver and front passenger knee airbags, side-impact head airbags, front seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning and available night vision systems.

